×
Entrez Id:
10215
Gene Symbol:
OLIG2
OLIG2
0.010
Biomarker
disease
BEFREE
We conclude that GC-GBM is a distinctive subtype of glioma characterized by its vulnerability to DNA damage and that wild-type TERTp and lower OLIG2 function might induce this feature.
31655917
2020
×
Entrez Id:
7157
Gene Symbol:
TP53
TP53
0.340
GeneticVariation
disease
BEFREE
Previously, single-gene study identified genetic changes in TP53 , PTEN and TERT promoter mutation in gcGBM .
30861589
2019
×
Entrez Id:
5728
Gene Symbol:
PTEN
PTEN
0.020
GeneticVariation
disease
BEFREE
Previously, single-gene study identified genetic changes in TP53, PTEN and TERT promoter mutation in gcGBM .
30861589
2019
×
Entrez Id:
29072
Gene Symbol:
SETD2
SETD2
0.010
GeneticVariation
disease
BEFREE
On top of the reported mutations, WES revealed ATRX, PIK3R1, RB1 and SETD2 as the recurrent mutations in gcGBM .
30861589
2019
LOC110806263
0.010
GeneticVariation
disease
BEFREE
Previously, single-gene study identified genetic changes in TP53, PTEN and TERT promoter mutation in gcGBM .
30861589
2019
×
Entrez Id:
159989
Gene Symbol:
DEUP1
DEUP1
0.300
Biomarker
disease
CTD_human
Identification of recurrent fusion genes across multiple cancer types.
30705370
2019
×
Entrez Id:
90355
Gene Symbol:
MACIR
MACIR
0.300
Biomarker
disease
CTD_human
Identification of recurrent fusion genes across multiple cancer types.
30705370
2019
SLC22A10
0.300
Biomarker
disease
CTD_human
Identification of recurrent fusion genes across multiple cancer types.
30705370
2019
×
Entrez Id:
7158
Gene Symbol:
TP53BP1
TP53BP1
0.300
Biomarker
disease
CTD_human
Identification of recurrent fusion genes across multiple cancer types.
30705370
2019
×
Entrez Id:
2898
Gene Symbol:
GRIK2
GRIK2
0.300
Biomarker
disease
CTD_human
Identification of recurrent fusion genes across multiple cancer types.
30705370
2019
×
Entrez Id:
60487
Gene Symbol:
TRMT11
TRMT11
0.300
Biomarker
disease
CTD_human
Identification of recurrent fusion genes across multiple cancer types.
30705370
2019
×
Entrez Id:
2475
Gene Symbol:
MTOR
MTOR
0.300
Biomarker
disease
CTD_human
Identification of recurrent fusion genes across multiple cancer types.
30705370
2019
×
Entrez Id:
65084
Gene Symbol:
TMEM135
TMEM135
0.300
Biomarker
disease
CTD_human
Identification of recurrent fusion genes across multiple cancer types.
30705370
2019
×
Entrez Id:
902
Gene Symbol:
CCNH
CCNH
0.300
Biomarker
disease
CTD_human
Identification of recurrent fusion genes across multiple cancer types.
30705370
2019
×
Entrez Id:
55379
Gene Symbol:
LRRC59
LRRC59
0.300
Biomarker
disease
CTD_human
Identification of recurrent fusion genes across multiple cancer types.
30705370
2019
×
Entrez Id:
51593
Gene Symbol:
SRRT
SRRT
0.300
Biomarker
disease
CTD_human
Knockdown of arsenic resistance protein 2 inhibits human glioblastoma cell proliferation through the MAPK/ERK pathway.
30542699
2018
×
Entrez Id:
5426
Gene Symbol:
POLE
POLE
0.010
GeneticVariation
disease
BEFREE
Germline mutation p.N363K in POLE is associated with an increased risk of colorectal cancer and giant cell glioblastoma .
30368636
2019
×
Entrez Id:
6046
Gene Symbol:
BRD2
BRD2
0.300
Biomarker
disease
CTD_human
OTX015 (MK-8628), a novel BET inhibitor, displays in vitro and in vivo antitumor effects alone and in combination with conventional therapies in glioblastoma models.
27388964
2016
×
Entrez Id:
23476
Gene Symbol:
BRD4
BRD4
0.300
Biomarker
disease
CTD_human
OTX015 (MK-8628), a novel BET inhibitor, displays in vitro and in vivo antitumor effects alone and in combination with conventional therapies in glioblastoma models.
27388964
2016
×
Entrez Id:
8425
Gene Symbol:
LTBP4
LTBP4
0.300
Biomarker
disease
CTD_human
Clonal evolution of glioblastoma under therapy.
27270107
2016
×
Entrez Id:
4255
Gene Symbol:
MGMT
MGMT
0.510
GeneticVariation
disease
BEFREE
Our data indicate, that in addition to the histological and immunohistochemical evaluation, investigation of MGMT promoter methylation and in particular BRAF V600E mutations represent reliable additional tools to sustain differentiation of gcGBM from PXA on a molecular basis.
27253461
2016
×
Entrez Id:
3417
Gene Symbol:
IDH1
IDH1
0.310
GeneticVariation
disease
BEFREE
IDH1 R132 and IDH R172 mutations were not present in any of the PXA and gcGBM cases.
27253461
2016
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
0.040
GeneticVariation
disease
BEFREE
Our data indicate, that in addition to the histological and immunohistochemical evaluation, investigation of MGMT promoter methylation and in particular BRAF V600E mutations represent reliable additional tools to sustain differentiation of gcGBM from PXA on a molecular basis.
27253461
2016
×
Entrez Id:
3418
Gene Symbol:
IDH2
IDH2
0.010
GeneticVariation
disease
BEFREE
IDH1 R132 and IDH R172 mutations were not present in any of the PXA and gcGBM cases.
27253461
2016
×
Entrez Id:
3014
Gene Symbol:
H2AX
H2AX
0.300
Biomarker
disease
CTD_human
Kynurenine Signaling Increases DNA Polymerase Kappa Expression and Promotes Genomic Instability in Glioblastoma Cells.
26651356
2016